📂 Anatomy
core-binding factor complex — Definition
Çekirdek bağlayıcı faktör kompleksi / core-binding factor complex
The core binding factor complex is a transcription factor that plays a critical role in the differentiation of hematopoetic cells. This complex consisting of RUNX1 and CBFβ subunits regulates the expression of target genes by connecting to DNA. The clinical significance is associated with function disorder, especially due to translocations (e.g. inv(16) or t(8;21). These mutations lead to uncontrolled reproduction of leukemia cells and are used as a diagnostic marker.
Frequently Asked Questions
❓ What is Çekirdek bağlayıcı faktör kompleksi?
Çekirdek bağlayıcı faktör kompleksi; the core binding factor complex is a transcription factor that plays a critical role in the differentiation of hematopoetic cells. This complex consisting of RUNX1 and CBFβ subunits regulates the expression of target genes by connecting to DNA. The clinical significance is associated with function disorder, especially due to translocations (e.g. inv(16) or t(8;21). These mutations lead to uncontrolled reproduction of leukemia cells and are used as a diagnostic marker.
❓ What is core-binding factor complex in Turkish?
The Turkish equivalent of "core-binding factor complex" is Çekirdek bağlayıcı faktör kompleksi.
❓ Which medical field is Çekirdek bağlayıcı faktör kompleksi related to?
This term belongs to the Anatomy category.