📂 Diseases
linear IgA bullous dermatosis — Definition
Lineer IgA büllöz dermatozu / linear IgA bullous dermatosis
Linear IgA is a disease of the autoimmune, characterized by subepidermal ribs in skin and mucous membranes. The disease is defined by the accumulation of linear IgA throughout the basal membrane and is often seen in children and adults. Observed with the clinically itching, stretched büller and vexins; often affects the body, limbs and perineal region. Drugs such as corticosteroids and dapson are used in treatment.
Disease Definition
🔬 Disease Definition
Lineer IgA büllöz dermatozu (LABD), deri ve mukoz membranlarda lineer IgA depozitleri ile karakterize, otoimmün subepidermal büllöz bir hastalıktır.
🧬 Causes & Risk Factors
Kesin neden bilinmemekle birlikte, otoimmün mekanizmalar rol oynar; bazı ilaçlar (örneğin vankomisin, NSAİİ'ler) tetikleyebilir.
🩺 Symptoms & Signs
Kaşıntılı, gergin büller (veziküller ve büller), eritemli plaklar, genellikle gövde, ekstremiteler ve kasıklarda simetrik dağılım; oral mukozada ülserasyonlar görülebilir.
📋 Diagnostic Methods
Klinik muayene, deri biyopsisi (subepidermal bül), direkt immünofloresan (lineer IgA depozitleri), indirekt immünofloresan ve ELISA ile anti-BP180/BP230 antikorları.
💊 Treatment Options
Hafif olgularda topikal kortikosteroidler; yaygın olgularda sistemik kortikosteroidler, dapson (birinci basamak), sülfonamidler, immünosupresifler (azatioprin, mikofenolat mofetil) veya biyolojik ajanlar (rituksimab).
⚠️ Complications
Enfeksiyon (bül rüptürü sonrası), skar oluşumu, hipopigmentasyon, ilaç yan etkileri (dapsona bağlı hemoliz, methemoglobinemi).
Frequently Asked Questions
❓ What is Lineer IgA büllöz dermatozu?
Lineer IgA büllöz dermatozu; linear IgA is a disease of the autoimmune, characterized by subepidermal ribs in skin and mucous membranes. The disease is defined by the accumulation of linear IgA throughout the basal membrane and is often seen in children and adults. Observed with the clinically itching, stretched büller and vexins; often affects the body, limbs and perineal region. Drugs such as corticosteroids and dapson are used in treatment.
❓ What is linear IgA bullous dermatosis in Turkish?
The Turkish equivalent of "linear IgA bullous dermatosis" is Lineer IgA büllöz dermatozu.
❓ Which medical field is Lineer IgA büllöz dermatozu related to?
This term belongs to the Diseases category.