📂 Diseases
epithelial basement membrane dystrophy — Definition
Epitel bazal membran distrofisi / epithelial basement membrane dystrophy
It is characterized by abnormal thickening and irregularization of basal membrane, which is located between the epithelium layer of the cornea, usually bilateral (double-sided) and non-compressive corneal dystrophy. One of the most common corneal dystrophys, can lead to recurrent cornea erosions, blurred vision and foreign body feeling in patients. In biomicroscopic examination, opasites appear in the corneal epithelium in the form of map-benzeri, spotual and fingerprint. Artificial tear in treatment, hypertonic solutions and laser or surgical debridman can be applied in severe cases.
Disease Definition
🔬 Disease Definition
Epitelyal bazal membran distrofisi (EBMD), korneanın epitelyal bazal membranını etkileyen, genellikle bilateral ve simetrik seyreden bir kornea distrofisidir. En sık görülen anterior kornea distrofisidir ve genellikle iyi huylu seyreder.
🧬 Causes & Risk Factors
Genetik mutasyonlar (TGFBI geni) ile ilişkilidir; otozomal dominant geçiş gösterir. Travma, kontakt lens kullanımı veya kuru göz gibi faktörler semptomları tetikleyebilir.
🩺 Symptoms & Signs
Tekrarlayan kornea erozyonları (özellikle sabah uyanınca ağrı, batma, ışığa hassasiyet), bulanık görme, yabancı cisim hissi, epitelyal mikrokistler ve haritalar (maps), noktalar (dots) ve parmak izi (fingerprints) şeklinde görülebilir.
📋 Diagnostic Methods
Yarıklı lamba biyomikroskopisi ile karakteristik bulguların (epitelyal mikrokistler, harita, nokta, parmak izi desenleri) görülmesi; konfokal mikroskopi ve optik koherens tomografi (OCT) yardımcı olabilir.
💊 Treatment Options
Semptomatik tedavi: suni gözyaşı, hipertonik solüsyonlar, bandaj kontakt lens, topikal antibiyotikler (erozyon durumunda). Şiddetli vakalarda epitelyal debridman, fototerapötik keratektomi (PTK) veya lazer ablasyon.
⚠️ Complications
Tekrarlayan kornea erozyonları, kornea skarlaşması, görme azalması, sekonder enfeksiyon riski.
Frequently Asked Questions
❓ What is Epitel bazal membran distrofisi?
Epitel bazal membran distrofisi; it is characterized by abnormal thickening and irregularization of basal membrane, which is located between the epithelium layer of the cornea, usually bilateral (double-sided) and non-compressive corneal dystrophy. One of the most common corneal dystrophys, can lead to recurrent cornea erosions, blurred vision and foreign body feeling in patients. In biomicroscopic examination, opasites appear in the corneal epithelium in the form of map-benzeri, spotual and fingerprint. Artificial tear in treatment, hypertonic solutions and laser or surgical debridman can be applied in severe cases.
❓ What is epithelial basement membrane dystrophy in Turkish?
The Turkish equivalent of "epithelial basement membrane dystrophy" is Epitel bazal membran distrofisi.
❓ Which medical field is Epitel bazal membran distrofisi related to?
This term belongs to the Diseases category.